General information about treatment in Seoul, published by Forever Clinic Myeongdong for international patients. Our own approach, physicians and prices are on the pages linked at the end.
If you’re planning a medical beauty trip to Korea, you’ve likely come across two names that dominate the conversation: Rejuran Healer and Botox. Both are incredibly popular injectable treatments offered at top clinics across Seoul’s Gangnam district, but they work in fundamentally different ways. Understanding the distinction between Rejuran Healer Korea vs Botox can help you make a more informed decision — and potentially combine both treatments for optimal results.
Rejuran Healer is a skin bio-remodeling treatment developed in South Korea using polynucleotide (PN) technology derived from salmon DNA. It was first approved by the Korean Ministry of Food and Drug Safety (MFDS) and has since become a staple treatment at leading Korean dermatology clinics. Unlike many cosmetic injectables, Rejuran works by stimulating your skin’s own regenerative processes rather than simply filling or freezing.
The treatment involves micro-injections of PN solution into the mid-to-deep dermis layer of the skin. Once injected, the polynucleotides promote collagen synthesis, improve skin elasticity, reduce fine lines, and restore moisture balance from within. According to a clinical study published in the Journal of Cosmetic Dermatology, PN-based injectables showed statistically significant improvement in skin hydration and elasticity after just three sessions.
Botox (botulinum toxin type A) is one of the most well-known cosmetic injectables in the world. It works by temporarily paralyzing specific facial muscles, preventing them from contracting and thereby reducing the appearance of dynamic wrinkles — those caused by repetitive movements like smiling, squinting, or frowning. Botox does not stimulate collagen or repair skin tissue; it simply relaxes muscle activity.
In Korea, Botox is used not only for wrinkle reduction but also for facial contouring, specifically to slim the jawline by targeting the masseter muscle. It is also used for brow lifting, neck bands (platysmal bands), and hyperhidrosis (excessive sweating).
To truly understand the Rejuran Healer Korea vs Botox comparison, it helps to look at them side by side across several important categories.
Rejuran Healer works biologically — it heals and rebuilds skin by promoting cellular regeneration. Botox works neurologically — it blocks nerve signals to muscles, temporarily stopping muscle contraction. One is a regenerative treatment; the other is a muscle relaxant.
Rejuran is ideal for patients concerned with skin quality — dullness, dehydration, acne scarring, fine texture, and early aging signs. Botox is ideal for patients concerned with expression lines, muscle-related aging, and facial reshaping. In many cases, patients in Korea receive both treatments during the same clinic visit for complementary benefits.
Botox results typically last 3–6 months, after which the muscle activity returns and maintenance injections are required. Rejuran Healer results, particularly when completed as a full 3-session course (spaced 3–4 weeks apart), can last 6–12 months or longer, with ongoing improvement due to cumulative collagen stimulation.
Both treatments involve minimal downtime. With Rejuran, patients may experience mild swelling, redness, or small bumps at injection sites for 24–48 hours. With Botox, side effects are rare but can include temporary bruising or, in rare cases, asymmetry if the toxin migrates. Both are considered low-risk procedures when performed by experienced practitioners.
One of the primary reasons international patients travel to Korea for aesthetic treatments is cost. Korean clinics offer world-class procedures at significantly lower prices than comparable clinics in the US, UK, or Australia.
A single Rejuran Healer session at a reputable Seoul clinic typically costs between ₩150,000–₩350,000 (approximately $110–$260 USD). A recommended course of three sessions ranges from ₩400,000–₩900,000 (approximately $295–$665 USD). Prices vary based on clinic reputation, the specific Rejuran variant used (standard, Rejuran S for scars, Rejuran I for eyes), and the treating physician’s experience level. For a full breakdown, visit our
Botox pricing in Korea is typically charged per unit or per area. Expect to pay ₩3,000–₩8,000 per unit (approximately $2.20–$5.90 USD). A standard forehead and frown line treatment using 40–60 units might cost ₩150,000–₩480,000 ($110–$355 USD). Jaw slimming Botox (masseter injections) commonly runs ₩200,000–₩500,000 ($148–$370 USD) per session.
Absolutely — and in fact, many Korean dermatologists actively recommend combining the two.
A common combination protocol involves receiving Botox first to relax the target muscles, followed by a Rejuran Healer session to improve overall skin quality during the same visit or shortly after. This approach is particularly popular among international patients who want to maximize results during a single trip to Korea.
Rejuran Healer is the better choice if your primary concern is skin quality — if you’re dealing with dull, dehydrated, or uneven skin, acne scars, or early signs of aging such as fine lines and loss of elasticity. It’s also highly recommended for patients who prefer regenerative, longer-lasting results and those who want a more natural approach to skin improvement. Learn more about real patient outcomes in our gallery.
Botox is the better choice if your primary concern is expression lines or facial contouring. If you’re bothered by crow’s feet, forehead lines, frown lines, or a square jaw, Botox delivers fast and highly targeted results. It’s also the go-to treatment for patients seeking immediate visible improvement before a major event.
Whether you’re choosing Rejuran Healer, Botox, or both, selecting the right clinic is essential. Look for clinics staffed by dermatology or plastic-surgery specialists with documented experience treating international patients. Clinics in Seoul’s Gangnam district lead in both volume and expertise. Additionally, our comprehensive guide provides practical advice on navigating the process as an international patient.
They target different aspects of aging. Rejuran Healer addresses skin quality, texture, and collagen loss, making it better for overall skin rejuvenation. Botox is better for specific dynamic wrinkles caused by muscle movement. Many patients benefit most from combining both treatments.
Rejuran Healer results from a full 3-session course can last 6–12 months or more due to its regenerative properties. Botox results typically last 3–6 months before a touch-up is needed.
It is generally considered safe, but your treating physician will assess your individual skin condition and recommend the optimal sequence and timing for both procedures.
A combined treatment package — including a Rejuran Healer session and a standard Botox treatment — could range from approximately ₩300,000–₩850,000 ($220–$630 USD) depending on the clinic and the extent of Botox treatment areas.
Yes, a consultation with a qualified Korean dermatologist is strongly recommended. During this assessment, the doctor will evaluate your skin condition, discuss your concerns and goals, and recommend the most appropriate treatment or combination protocol for your unique needs.
Both treatments have minimal downtime. Rejuran Healer may cause mild swelling or small papules at injection points for 24–48 hours. Botox may cause minor bruising but results in virtually no downtime. Most international patients are comfortable continuing sightseeing in Seoul the same day or the day after either treatment.
Send your dates and your concern on WhatsApp. Consultation is conducted in English, and a plan with an itemised quote follows the assessment.