Last Updated: April 2026 | Reviewed by: Korea Medical Tourism Editorial Team
Rejuran vs Profhilo in Korea: A Head-to-Head Comparison
Patients visiting Korean clinics consistently report that the most common question they ask during their first consultation is whether to choose Rejuran Healer or Profhilo — and the answer is rarely straightforward. Korea has become a global leader in skin biorevitalization, with the Korean Ministry of Health and Welfare (mohw.go.kr) reporting a consistent rise in medical tourism related to non-surgical aesthetic injectables, particularly among patients from Southeast Asia, Australia, and North America. What surprises many first-time visitors is that Rejuran Healer, developed and manufactured in Korea using salmon-derived PDRN (Polynucleotide), is significantly more established in Korean dermatology clinics than Profhilo, which remains an Italian import — and the price difference between the two reflects exactly that dynamic.
Understanding the distinction between these two treatments requires more than reading a product brochure. Rejuran works at the cellular level by stimulating DNA repair and tissue regeneration, while Profhilo relies on a high concentration of hyaluronic acid to remodel the skin’s architecture through biostimulation. Both are injectable, minimally invasive, and deliver impressive skin quality improvements — but they are formulated differently, work through different biological mechanisms, and suit different skin concerns. This guide breaks down everything international patients need to know before booking a session in Seoul.
Clinical Perspective: A board-certified dermatologist practicing in Gangnam notes: “When patients ask me to choose between Rejuran and Profhilo, I always ask them two questions: Are you primarily concerned with skin texture and healing, or with laxity and hydration volume? Rejuran is our go-to for patients with post-acne scarring, enlarged pores, or compromised skin barrier function. Profhilo excels when the concern is overall skin slackening and deep moisture deficiency. In many cases, we actually sequence both treatments across separate sessions for patients who want comprehensive skin rejuvenation.”
How Rejuran and Profhilo Work Differently
The Science Behind Rejuran Healer
Rejuran Healer contains PDRN, a polynucleotide derived from salmon DNA that has been scientifically shown to activate tissue regeneration by binding to adenosine A2A receptors in skin cells. When injected intradermally, it triggers collagen synthesis, reduces inflammation, and promotes cellular turnover. According to research published on PubMed (NCBI), PDRN-based therapies have demonstrated measurable improvements in skin elasticity, hydration, and wound healing markers in multiple peer-reviewed clinical studies. This makes Rejuran especially suitable for patients dealing with acne scarring, post-procedural recovery, sun damage, and overall skin thinning caused by aging.
The Science Behind Profhilo
Profhilo contains one of the highest concentrations of hyaluronic acid available in any injectable product — 64mg per 2ml — formulated through a patented thermal process called NAHYCO technology. Unlike traditional dermal fillers, Profhilo does not add volume or structure. Instead, it spreads slowly beneath the skin after injection into specific BAP (Bio Aesthetic Points), stimulating four types of collagen and elastin simultaneously. The result is a notable improvement in skin laxity, hydration, and overall luminosity. It is particularly effective for patients in their late 30s to 50s who are beginning to notice skin looseness on the face, neck, or décolletage.
Price Comparison: Rejuran vs Profhilo in Korea
Rejuran Healer Pricing in Seoul Clinics
Clinics across Gangnam and Apgujeong typically charge between ₩150,000 and ₩350,000 (approximately USD $110–$260) per session for a standard Rejuran Healer treatment. A full course is generally three sessions spaced two to four weeks apart, bringing the total investment to ₩450,000–₩1,050,000 (USD $330–$780). Some premium clinics offering combination Rejuran protocols — such as Rejuran I for under-eye areas or Rejuran S for acne-prone skin — may charge slightly higher rates. Maintenance sessions after the initial course typically range from ₩180,000 to ₩250,000 (USD $135–$185) every three to six months.
Profhilo Pricing in Seoul Clinics
Because Profhilo is an imported product not manufactured domestically in Korea, pricing tends to be higher than Rejuran. International patients can expect to pay between ₩400,000 and ₩700,000 (approximately USD $295–$520) per session at reputable clinics in the Gangnam district. A standard treatment protocol involves two sessions spaced four weeks apart, meaning the full initial course typically costs between ₩800,000 and ₩1,400,000 (USD $590–$1,040). Maintenance is recommended every six months. While Profhilo is more expensive per session in Korea, it remains considerably cheaper than what patients would pay in London, Sydney, or New York, where a single session routinely exceeds USD $800.
Procedure Experience, Timeline, and Recovery
What to Expect During a Rejuran Session
A standard Rejuran Healer session takes approximately 30 to 45 minutes from consultation to completion. Numbing cream is applied 20 to 30 minutes before treatment. The injections are administered via a fine-gauge needle or microneedle device across the face in a grid-like pattern, with most patients receiving 50 to 100 small microinjections per session. Mild redness, small bumps (papules), and swelling are normal immediately after treatment and typically resolve within 24 to 48 hours. Most international patients are comfortable attending light social engagements the following day, though high-heat environments and heavy exercise should be avoided for 48 hours post-treatment.
What to Expect During a Profhilo Session
Profhilo is administered at only five injection points per side of the face using the BAP technique, making it a notably faster and less uncomfortable procedure than Rejuran. Sessions typically last 20 to 30 minutes. Post-injection, small lumps may appear at each injection site but generally dissolve within 24 hours as the product disperses beneath the skin. Recovery is minimal — most patients experience little to no downtime and can resume normal activities the same day. Final results from the two-session protocol are typically visible within four to eight weeks after the second treatment, with skin appearing noticeably firmer, more hydrated, and luminous.
Which Treatment Is Right for You?
Choose Rejuran If…
Rejuran Healer is the better choice if your primary skin concerns include enlarged pores, acne scarring, uneven skin texture, post-inflammatory redness, or overall skin thinning. It is also recommended for patients who have undergone laser resurfacing or other ablative procedures and want to accelerate healing and enhance results. Younger patients in their 20s and 30s who want to treat specific skin damage rather than general aging changes also tend to see outstanding results with Rejuran.
Choose Profhilo If…
Profhilo is the stronger option for patients experiencing early skin laxity, loss of facial volume definition, or pervasive dryness that does not respond well to topical treatments. It is ideal for patients in their late 30s, 40s, and 50s who want a global skin quality improvement without the use of traditional fillers or threads. It is also commonly recommended for off-face areas such as the neck, hands, and décolletage, where Rejuran is less frequently used.
What to Know Before You Book
Based on our research across multiple Gangnam clinics, here are the most important practical considerations for international patients comparing rejuran vs profhilo korea options before booking a treatment:
- Confirm product authenticity before treatment. Clinics we contacted confirmed that both genuine Rejuran and authentic Profhilo products should be presented to patients in their original sealed packaging before injection. Ask your clinic to show you the product vial and batch number.
- Plan your trip around your treatment schedule. A full Rejuran course requires three visits over six to eight weeks, while Profhilo requires two visits over four weeks. International patients with shorter itineraries may need to book one session and schedule follow-ups on a return trip.
- Request a patch test if you have known sensitivities. Although allergic reactions to PDRN are rare, clinics we contacted across Seoul recommend a brief consultation and patch assessment for patients with seafood or fish allergies before Rejuran treatment.
- Translation support is widely available. Most reputable clinics in Gangnam and Apgujeong have English-speaking staff or professional interpreters available. Confirm this when making your booking inquiry.
- Combination packages offer better value. Many Seoul clinics offer combination packages that include both Rejuran and Profhilo in a sequenced protocol. Based on our research, these combination packages often provide 15–25% savings compared to booking each treatment separately.
Frequently Asked Questions
Can I get both Rejuran and Profhilo done on the same trip to Korea?
Yes, many clinics in Seoul offer sequenced combination protocols that include both treatments. However, they are rarely administered on the same day. Most clinics recommend spacing Rejuran and Profhilo sessions at least one to two weeks apart to allow the skin to respond optimally to each treatment. If you are planning a longer stay of two to three weeks, you can realistically complete one session of each during your trip.
Which treatment lasts longer — Rejuran or Profhilo?
Results from a full Rejuran course typically last six to twelve months, depending on the patient’s age, skin condition, and lifestyle factors. Profhilo results from the standard two-session protocol generally last six to nine months before a maintenance session is recommended. Both treatments require periodic maintenance to sustain results, though the regenerative effects of Rejuran — particularly collagen remodeling — tend to compound positively with repeated courses over time.
Is Rejuran Healer cheaper in Korea than in other countries?
Significantly so. Rejuran Healer is manufactured in Korea by PHARMOS BIOPHARMA, which means Korean clinics have direct access to the product at domestic supply prices. International patients frequently report saving 40–60% compared to what they would pay for equivalent treatments in Singapore, Australia, or the United Kingdom. This cost advantage is one of the primary reasons medical tourists specifically travel to Korea for Rejuran treatment.
Is Profhilo available across all clinics in Korea?
Profhilo is available in Korea but is less universally stocked than Rejuran, given that it is an imported product. It is most reliably available at mid-to-premium tier dermatology clinics in Gangnam, Apgujeong, and Sinchon. When booking, always confirm product availability in advance and ask the clinic to confirm the current batch and expiry details of the Profhilo they stock.
Are there any risks or side effects I should know about?
Both Rejuran and Profhilo carry a low side effect profile when administered by qualified practitioners. The most common side effects for both treatments include temporary redness, swelling, and minor bruising at injection sites, typically resolving within 24 to 72 hours. Serious adverse events are rare but include infection, vascular occlusion (extremely rare with superficial injections), and allergic reaction. Always ensure your treatment is performed by a licensed dermatologist or plastic surgeon in a registered medical facility. The American Academy of Dermatology provides useful general guidance on injectable treatment safety that international patients may find helpful when evaluating risks.
Related Articles
- Rejuran Healer Cost in Korea: Full Pricing Guide
- Rejuran Healer Korea Treatment Guide 2026
- Rejuran Healer Korea vs Botox: Key Differences Explained
- How to Find the Best Rejuran Healer Clinic in Korea
- Rejuran Healer in Korea for Foreign Patients: What to Expect